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1

mRNA-based therapeutics — developing a new class of drugs

Sahin, Ugur, Karikó, Katalin, Türeci, Özlem

Journal:

Nature Reviews Drug Discovery

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

2

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Stadler, Christiane R, Bähr-Mahmud, Hayat, Celik, Leyla, Hebich, Bernhard, Roth, Alexandra S, Roth, René P, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur

Journal:

Nature Medicine

Year:

2017

Language:

english

File:

PDF, 833 KB

english, 2017

3

Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Nonradioactive Measurement of Cellular and Humoral Cytotoxicity

Omokoko, Tana A., Luxemburger, Uli, Bardissi, Shaheer, Simon, Petra, Utsch, Magdalena, Breitkreuz, Andrea, Türeci, Özlem, Sahin, Ugur

Journal:

Journal of Immunology Research

Year:

2016

Language:

english

File:

PDF, 2.10 MB

english, 2016

4

Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide

Schumacher, Jens, Bacic, Tijana, Staritzbichler, René, Daneschdar, Matin, Klamp, Thorsten, Arnold, Philipp, Jägle, Sabrina, Türeci, Özlem, Markl, Jürgen, Sahin, Ugur

Journal:

Journal of Nanobiotechnology

Year:

2018

Language:

english

File:

PDF, 3.83 MB

english, 2018

5

Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

Vormehr, Mathias, Schrörs, Barbara, Boegel, Sebastian, Löwer, Martin, Türeci, Özlem, Sahin, Ugur

Journal:

Journal of Immunology Research

Year:

2015

Language:

english

File:

PDF, 1.60 MB

english, 2015

6

Tumor vaccination using messenger RNA: prospects of a future therapy

Sebastian Kreiter, Mustafa Diken, Abderraouf Selmi, Özlem Türeci, Ugur Sahin

Journal:

Current Opinion in Immunology

Year:

2011

Language:

english

File:

PDF, 545 KB

english, 2011

7

mRNA as a Versatile Tool for Exogenous Protein Expression

N. Kuhn, Andreas, Beißert, Tim, Simon, Petra, Vallazza, Britta, Buck, Janina, P. Davies, Brian, Tureci, Ozlem, Sahin, Ugur

Journal:

Current Gene Therapy

Year:

2012

Language:

english

File:

PDF, 389 KB

english, 2012

8

Characterization of the First-in-Class T-Cell Engaging Bispecific Single-Chain Antibody for Targeted Immunotherapy of Solid Tumors Expressing the Oncofetal Protein Claudin 6

Stadler, Christiane R, Bähr-Mahmud, Hayat, Plum, Laura M, Schmoldt, Kathrin, Kölsch, Anne C, Türeci, Özlem, Sahin, Ugur

Journal:

Year:

2015

Language:

english

File:

PDF, 3.72 MB

english, 2015

9

Personalized vaccines for cancer immunotherapy

Sahin, Ugur, Türeci, Özlem

Journal:

Year:

2018

Language:

english

File:

PDF, 1.15 MB

english, 2018

10

Efficient reprogramming of human fibroblasts and blood-derived endothelial progenitor cells using non-modified RNA for reprogramming and immune evasion

Poleganov, Marco Alexander, Eminli, Sarah, Beissert, Tim, Herz, Stephanie, Moon, Jung-Il, Goldmann, Johanna, Beyer, Arianne, Heck, Rosario, Burkhart, Isabell, Barea Roldan, Diana, Türeci, Özlem, Yi, K

Journal:

Human Gene Therapy

Year:

2015

Language:

english

File:

PDF, 3.24 MB

english, 2015

11

Targeting the tumor vasculature with engineered cystine-knot miniproteins

Lui, Bonny Gaby, Salomon, Nadja, Wüstehube-Lausch, Joycelyn, Daneschdar, Matin, Schmoldt, Hans-Ulrich, Türeci, Özlem, Sahin, Ugur

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 1.72 MB

english, 2020

12

Efficacy of intravenous paracetamol, metamizol and lornoxicam on postoperative pain and morphine consumption after lumbar disc surgery

Korkmaz Dilmen, Ozlem, Tunali, Yusuf, Cakmakkaya, Ozlem S, Yentur, Ercument, Tutuncu, Ayse C, Tureci, Ercan, Bahar, Mois

Journal:

European Journal of Anaesthesiology

Year:

2010

Language:

english

File:

PDF, 209 KB

english, 2010

13

Mutanome directed cancer immunotherapy

Vormehr, Mathias, Diken, Mustafa, Boegel, Sebastian, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

Journal:

Current Opinion in Immunology

Year:

2016

Language:

english

File:

PDF, 1.15 MB

english, 2016

14

A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer

Sahin, Ugur, Schuler, Martin, Richly, Heike, Bauer, Stefan, Krilova, Anna, Dechow, Tobias, Jerling, Markus, Utsch, Magdalena, Rohde, Christoph, Dhaene, Karl, Huber, Christoph, Türeci, Özlem

Journal:

European Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 1.14 MB

english, 2018

15

Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics

Kuhn, Andreas N., Diken, Mustafa, Kreiter, Sebastian, Vallazza, Britta, Türeci, Özlem, Sahin, Ugur

Journal:

Year:

2011

Language:

english

File:

PDF, 448 KB

english, 2011

16

Challenges towards the realization of individualized cancer vaccines

Türeci, Özlem, Löwer, Martin, Schrörs, Barbara, Lang, Maren, Tadmor, Arbel, Sahin, Ugur

Journal:

Nature Biomedical Engineering

Year:

2018

Language:

english

File:

PDF, 1017 KB

english, 2018

17

A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

Beissert, Tim, Perkovic, Mario, Vogel, Annette, Erbar, Stephanie, Walzer, Kerstin C., Hempel, Tina, Brill, Silke, Haefner, Erik, Becker, René, Türeci, Özlem, Sahin, Ugur

Journal:

Molecular Therapy

Year:

2019

Language:

english

File:

PDF, 1.10 MB

english, 2019

18

Rapid molecular dissection of viral and bacterial immunomes

Ugur Sahin, Özlem Türeci, Claudine Graf, Ralf G. Meyer, Volker Lennerz, Cedrik M. Britten, Claudia Dumrese, Elke Scandella, Thomas Wölfel, Burkhard Ludewig

Journal:

European Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 341 KB

english, 2006

19

Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues

Thorsten Klamp, Ugur Sahin, Bruno Kyewski, Jochen Schwendemann, Karl Dhaene, Özlem Türeci

Journal:

Immunology Letters

Year:

2006

Language:

english

File:

PDF, 273 KB

english, 2006

20

Simultaneous ex vivo quantification of antigen-specific CD4+and CD8+T cell responses using in vitro transcribed RNA

Sebastian Kreiter, Thorsten Konrad, Martina Sester, Christoph Huber, Özlem Türeci, Ugur Sahin

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 588 KB

english, 2007

21

CrELISA: a fast and robust enzyme-linked immunosorbent assay bypassing the need for purification of recombinant protein

Özlem Türeci, Uli Luxemburger, Helma Heinen, Ulrich Mack, Gerhard W Sybrecht, Christoph Huber, Ugur Sahin

Journal:

Journal of Immunological Methods

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

22

Selective activation of tumor growth-promoting Ca2+channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2

Michael Koslowski, Özlem Türeci, Christoph Huber, Ugur Sahin

Journal:

Molecular Cancer

Year:

2009

Language:

english

File:

PDF, 1.15 MB

english, 2009

23

Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma

Rohde, Christoph, Yamaguchi, Rin, Mukhina, Svetlana, Sahin, Ugur, Itoh, Kyogo, Türeci, Özlem

Journal:

Japanese Journal of Clinical Oncology

Year:

2019

Language:

english

File:

PDF, 655 KB

english, 2019

24

Expression of multiple cancer/testis (CT) antigens in breast cancer and melanoma: Basis for polyvalent CT vaccine strategies

Ugur Sahin, Özlem Türeci, Yao-Tseng Chen, Gerhard Seitz, Carlos Villena-Heinsen, Lloyd J. Old, Michael Pfreundschuh

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 53 KB

english, 1998

25

Improvement of in vivo expression of genes delivered by self-amplifying RNA using Vaccinia Virus immune evasion proteins

Beissert, Tim, Koste, Lars, Perkovic, Mario, Walzer, Kerstin C., Erbar, Stephanie, Selmi, Abderaouf, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

Journal:

Human Gene Therapy

Year:

2017

Language:

english

File:

PDF, 1.66 MB

english, 2017

26

Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1

Özlem Türeci, Ulrich Mack, Ulrich Luxemburger, Helma Heinen, Frank Krummenauer, Martina Sester, Urban Sester, Gerhard W. Sybrecht, Ugur Sahin

Journal:

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

27

Peptide microarrays enable rapid mimotope optimization for pharmacokinetic analysis of the novel therapeutic antibody IMAB362

Schnatbaum, Karsten, Schmoldt, Hans-Ulrich, Daneschdar, Matin, Plum, Laura M., Jansong, Janina, Zerweck, Johannes, Kühne, Yvonne, Masch, Antonia, Wenschuh, Holger, Fiedler, Markus, Türeci, Özlem, Sahi

Journal:

Biotechnology Journal

Year:

2014

Language:

english

File:

PDF, 663 KB

english, 2014

28

Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity

Bellinghausen, Iris, Reuter, Sebastian, Martin, Helen, Maxeiner, Joachim, Luxemburger, Uli, Türeci, Özlem, Grabbe, Stephan, Taube, Christian, Saloga, Joachim

Journal:

Journal of Allergy and Clinical Immunology

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

29

Confidence-based Somatic Mutation Evaluation and Prioritization

Löwer, Martin, Renard, Bernhard Y., de Graaf, Jos, Wagner, Meike, Paret, Claudia, Kneip, Christoph, Türeci, Özlem, Diken, Mustafa, Britten, Cedrik, Kreiter, Sebastian, Koslowski, Michael, Castle, John

Journal:

PLoS Computational Biology

Year:

2012

Language:

english

File:

PDF, 1.61 MB

english, 2012

30

HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

Grunwitz, Christian, Salomon, Nadja, Vascotto, Fulvia, Selmi, Abderaouf, Bukur, Thomas, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

Journal:

Year:

2019

File:

PDF, 6.53 MB

2019

31

Targeting the tumor mutanome for personalized vaccination therapy

Kreiter, Sebastian, Castle, John C., Türeci, Özlem, Sahin, Ugur

Journal:

Year:

2012

Language:

english

File:

PDF, 449 KB

english, 2012

32

A Testicular Antigen Aberrantly Expressed in Human Cancers Detected by Autologous Antibody Screening

Yao-Tseng Chen, Matthew J. Scanlan, Ugur Sahin, Özlem Türeci, Ali O. Gure, Solam Tsang, Barbara Williamson, Elisabeth Stocker, Michael Pfreundschuh and Lloyd J. Old

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1004 KB

english, 1997

33

NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells

Wagner, Meike, Koslowski, Michael, Paret, Claudia, Schmidt, Marcus, Türeci, Özlem, Sahin, Ugur

Journal:

Year:

2013

Language:

english

File:

PDF, 497 KB

english, 2013

34

Human Carbonic Anhydrase XII: cDNA Cloning, Expression, and Chromosomal Localization of a Carbonic Anhydrase Gene that is Overexpressed in Some Renal Cell Cancers

Ozlem Tureci, Ugur Sahin, Evi Vollmar, Stefan Siemer, Elisabeth Gottert, Gerhard Seitz, Anna-Kaisa Parkkila, Gul N. Shah, Jeffrey H. Grubb, Michael Pfreundschuh and William S. Sly

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.69 MB

english, 1998

35

SSX: A multigene family with several members transcribed in normal testis and human cancer

Ali O. Gure, Özlem Türeci, Ugur Sahin, Solam Tsang, Matthew J. Scanlan, Elke Jäger, Alexander Knuth, Michael Pfreundschuh, Lloyd J. Old, Yao-Tseng Chen

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 180 KB

english, 1997

36

Identification of new claudin family members by a novel PSI-BLAST based approach with enhanced specificity

Jun Wu, Gerd Helftenbein, Michael Koslowski, Ugur Sahin, Özlem Tureci

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 201 KB

english, 2006

37

Serological identification of human tumor antigens

Ugur Sahin, Özlem Türeci, Michael Pfreundschuh

Journal:

Current Opinion in Immunology

Year:

1997

Language:

english

File:

PDF, 797 KB

english, 1997

38

In silico strategy for detection of target candidates for antibody therapy of solid tumors

Gerd Helftenbein, Michael Koslowski, Karl Dhaene, Gerhard Seitz, Ugur Sahin, Özlem Türeci

Journal:

Year:

2008

Language:

english

File:

PDF, 681 KB

english, 2008

39

Expression of serologically identified tumor antigens in acute leukemias

Philipp Niemeyer, Özlem Türeci, Thomas Eberle, Norbert Graf, Michael Pfreundschuh, Ugur Sahin

Journal:

Leukemia Research

Year:

2003

Language:

english

File:

PDF, 114 KB

english, 2003

40

rapmad: Robust analysis of peptide microarray data

Bernhard Y Renard, Martin Löwer, Yvonne Kühne, Ulf Reimer, Andrée Rothermel, Özlem Türeci, John C Castle, Ugur Sahin

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 391 KB

english, 2011

41

Human Neoplasms Elicit Multiple Specific Immune Responses in the Autologous Host

Ugur Sahin, Ozlem Tureci, Holger Schmitt, Bjorn Cochlovius, Thomas Johannes, Rudolf Schmits, Frank Stenner, Guorong Luo, Ingrid Schobert and Michael Pfreundschuh

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 818 KB

english, 1995

42

Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice

Selmi, Abderraouf, Vascotto, Fulvia, Kautz-Neu, Kordula, Türeci, Özlem, Sahin, Ugur, von Stebut, Esther, Diken, Mustafa, Kreiter, Sebastian

Journal:

Cancer Immunology, Immunotherapy

Year:

2016

Language:

english

File:

PDF, 853 KB

english, 2016

43

Expression of SSX genes in human tumors

Özlem Türeci, Yao-Tseng Chen, Ugur Sahin, Ali O. Güre, Carsten Zwick, Carlos Villena, Solam Tsang, Gerhard Seitz, Lloyd J. Old, Michael Pfreundschuh

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 74 KB

english, 1998

44

Intravenous delivery of the toll-like receptor 7 agonist SC1 confers tumor control by inducing a CD8+ T cell response

Vascotto, Fulvia, Petschenka, Jutta, Walzer, Kerstin C., Vormehr, Mathias, Brkic, Magdalena, Strobl, Stefan, Rösemann, Roman, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

Journal:

Year:

2019

File:

PDF, 3.88 MB

2019

45

Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals

Özlem Türeci, Michael Koslowski, Gerd Helftenbein, John Castle, Christoph Rohde, Karl Dhaene, Gerhard Seitz, Ugur Sahin

Journal:

Year:

2011

Language:

english

File:

PDF, 3.12 MB

english, 2011

46

Expression of a Novel Transmembrane Carbonic Anhydrase Isozyme XII in Normal Human Gut and Colorectal Tumors

Antti Kivelä, Seppo Parkkila, Juha Saarnio, Tuomo J. Karttunen, Jyrki Kivelä, Anna-Kaisa Parkkila, Abdul Waheed, William S. Sly, Jeffrey H. Grubb, Gul Shah, Özlem Türeci, Hannu Rajaniemi

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 1.74 MB

english, 2000

47

Mutated tumor alleles are expressed according to their DNA frequency

Castle, John C., Loewer, Martin, Boegel, Sebastian, Tadmor, Arbel D., Boisguerin, Valesca, de Graaf, Jos, Paret, Claudia, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 651 KB

english, 2015

48

Identification of a Meiosis-Specific Protein as a Member of the Class of Cancer/Testis Antigens

Ozlem Tureci, Ugur Sahin, Carsten Zwick, Michael Koslowski, Gerhard Seitz and Michael Pfreundschuh

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.63 MB

english, 1998

49

Autoimmunity seen through the SEREX-scope

Philippe Krebs, Michael Kurrer, Ugur Sahin, Özlem Türeci, Burkhard Ludewig

Journal:

Autoimmunity Reviews

Year:

2003

Language:

english

File:

PDF, 486 KB

english, 2003

50

Characterization of human colon cancer antigens recognized by autologous antibodies

Matthew J. Scanlan, Yao-Tseng Chen, Barbara Williamson, Ali O. Gure, Elisabeth Stockert, John D. Gordan, Özlem Türeci, Ugur Sahin, Michael Pfreundschuh, Lloyd J. Old

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 109 KB

english, 1998

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